Despite a spirited performance by the Black Stars in the second half; individual mistakes in a space of two minutes caused the Senior National team to collapse.
The Portuguese won a thrilling 3-2 at Stadium 974 in Doha on Thursday.
Cristiano Ronaldo got on the scoresheet following a 65th minute penalty.
Black Stars skipper, Andre Ayew equalized after a Kudus pass across the goal in the 73rd-minute to put a smile on the faces of the Ghanaian spectators.
However, quick goals from Joao Felix and Rafael Leao put the Portuguese back in control.
Osman Bukari pulled one back for Ghana in the 89th minute. But instead of rushing the ball back to the centre-circle to push for an equaliser, he insisted on mimicking Ronaldo’s trademark celebration.
The Black Stars will hope to make amends when they face South Korea in a dicey clash on Monday.